Education
University of California, Berkeley, CA B.A. 1962 Bact. Immunology
University of California, Berkeley, CA M.A. 1964 Bact. Immunology
University of California, Berkeley, CA Ph.D. 1967 Bact. Immunology

Professional Training
1963 - 1967 Graduate Student, Department of Bacteriology-Immunology, University of California.
1967 - 1969 Damon Runyon Post Doctoral Fellow, Department of Pathology, University of Washington.

FACULTY APPOINTMENTS
1969 - 1975 Assistant Professor of Bio-Med Science, Brown University and Department of Medicine, Roger Williams General Hospital
1975 - 1979 Associate Professor of Pathology, Brown University and Department of Medicine, Roger Williams General hospital
1979 - 1995 Chairman, Department of Immunology, Michigan Cancer Foundation (Karmanos Cancer Institute), Detroit, MI
1979 - Present Adjunct Professor, Department of Pathology, Wayne State University, Detroit, MI
1980 - 1983 Associate Member, Michigan Cancer Foundation (Karmanos Cancer Institute), Detroit, MI
1980 - 1988 Deputy Associate Director of Research, Comprehensive Cancer Center of Metropolitan Detroit (Karmanos Cancer Institute), Detroit, MI
1981 - 1991 Director of Laboratories, Michigan Cancer Foundation (Karmanos Cancer Institute), Det., MI
1983 - 1995 Member, Michigan Cancer Foundation (Karmanos Cancer Institute), Detroit, MI
1983 - 1988 Adjunct Professor, Department of Biological Science, Wayne State University, Detroit, MI
1984 - Present Department of Immunology and Microbiology, Wayne State University, Detroit, MI
1985 - 1991 Senior Vice President, Michigan Cancer Foundation (Karmanos Cancer Institute), Detroit, MI
1989 - 2003 Director of Breast Cancer Program, Comprehensive Cancer Center of Metropolitan Detroit (Karmanos Cancer Institute), Detroit, MI
1989 - Present Graduate Faculty Member, Cancer Biology Program, Wayne State University, Detroit, MI
1995 - Present Member, Karmanos Cancer Institute
1995 - 2003 Deputy Director, Karmanos Cancer Institute, Detroit, MI
1991 - Present Professor, Department of Internal Medicine
2002 - 2002 Interim Assistant Dean, Cancer Research, Wayne State University (January - October)
2003 - Present Associate Vice President, Division of Research, Wayne State University

Honors

1967 - 1969 Damon Runyon Fellow
1987 Michigan Science Trail-Blazer Award
1988 Herbert Fanger Memorial Lecturer, Rhode Island Hospital and Brown University
1988 Sarah Stewart Memorial Lecturer, Georgetown University
1991 Molly Rubin Award for Service to Humanity
1995 - 1997 Charles Gershenson Distinguished Faculty Fellow
1995 Member, WSU Academy of Scholars

Publications

1. Heppner, G.H. Cancer cell societies and tumor progression. Stem Cells. 11:199-203, 1993.
2. Miller, B.E., Miller, F.R., Machemer, T, Heppner G.H. Melphalan sensitivity as a function of progressive metastatic growth in two subpopulations of a mouse mammary tumour. Brit. J. Cancer, 68:18-25, 1993.
3. Miller, F.R., Soule, H.D., Tait, L., Pauley, R.J., Wolman, S.R., Dawson, P.J., Heppner, G.H. Xenograft model of progressive human proliferative breast disease. J. Natl. Cancer Inst., 85:1725-1732, 1993.
4. Pauley, R.J., Soule, H.D., Tait, L., Miller, F.R., Wolman, S.R., Dawson, P.J., Heppner, G.H. The MCF10 family of spontaneously immortalized human breast epithelial cell lines and models of neoplastic progression. Eur. J. of Cancer Prevention, 2:67-76, 1993.
5. Wolman, S.R., Mohamed, A.N., Heppner, G.H., Soule, H.D. Chromosomal markers of immortalization in human breast epithelium. Genes, Chromosomes and Cancer, 10:59-65, 1994.
6. Heppner, G.H., Miller, F.R., Guest Editors, Molecular Correlates of Tumor Progression In: Seminars in Cancer Biology. Saunders Scientific Publishing, 1993. Introduction, pp. 141-142.
7. Miller, B.E., Miller, F.R., Machemer, T, Heppner G.H. Melphalan sensitivity as a function of progressive metastatic growth in two subpopulations of a mouse mammary tumour. Brit. J. Cancer, 68:18-25, 1993.
8. Heppner, G.H. Cancer cell societies and tumor progression. Stem Cells. 11: 199 - 203, 1993.
9. Miller,F.R., Soule,H.D., Tait,L., Pauley,R.J., Wolman,S.R., Dawson,P.J., Heppner,G.H. Xenograft model of progressive human proliferative breast disease, J. Natl. Cancer Inst., 85:1725-1732, 1993.
10. Pauley,R.J., Soule,H.D., Tait,L., Miller,F.R., Wolman.S.R., Dawson,P.J., Heppner,G.H.,The MCF10 Family of spontaneously immortalized human breast epithelial cell lines and models of neoplastic progression. Eur. J. of Cancer Prevention, 2:67-76, 1993.
11. Heppner, G.H. The cellular bases of tumor progression. In: Anonymous Proceedings of the Eight International Conference of the International Society of differentiation. pp. 21 24, 1994.
12. Tsai, S.C. and Heppner, G.H. Immunoendocrine mechanisms in mammary tumor progression: direct prolactin modulation of peripheral and preneoplastic hyperplastic alveolar nodule infiltrating lymphocytes. Cancer Immunol. Immunother. 39: 291 298, 1994.
13. Wolman, S.R., Mohamed, A.N., Heppner, G.H., and Soule, H.D. Chromosomal markers of immortalization in human breast epithelium. Genes Chromosome. Cancer, 10: 59 65, 1994.
14. Wei, W.Z. and Heppner, G.H. Breast cancer immunology. In: Breast Cancer: Cellular and Molecular Biology. R. Dickson and M. Lippman (eds.),. 1995.
15. Dawson, P.J., Wolman, S.R., Tait, L., Heppner, G.H., and Miller, F.R. MCF10AT: A model for the evolution of cancer from proliferative breast disease. Amer. J. Path., 148:313-319, 1996.
16. Miller, B.E., Matherly, L.H., Lehotan, M., and Heppner, G.H. Role of heterogeneity in development of methotrexate resistance in heterogeneous mouse mammary tumor culture. J. Exp. Ther. And Oncol. 1:30-38, 1996.
17. Visscher,D.W., Heppner,G.H. The pathobiology of neoplasia. In: Principles of Medical Biology. E.E. Bittar, (Ed.), JAI Press, 1-41, 1996
18. Wolman, S.R., Heppner, G.H., Wolman, E. New directions in breast cancer research. FASEBJ 11:535-543,1997.
19. Shekhar, P.V.M., Nangia-Makker, P., Wolman, S., Tait, L., Heppner, G.H., Visscher, D.W. Direct action of estrogen on sequence of progression of human preneoplastic breast disease. Amer. J. Pathol. 152:1129-1132, 1998.
20. Heppner, G.H., Wolman, S.R. MCF10AT: a Model for Human Breast Cancer Development. The Breast Journal, 5:122-129, 1999.
21. Heppner, G.H., Wolman, S.R., Rosen, J., Solomon, D., Smith, G., & Mohla, S., Meeting Report: Research potential of a unique xenograft model of human proliferative breast disease. Breast Cancer Res and Treatment, 58:183-186, 1999.
22. Miller, F.R., Heppner, G.H. Xenograft models of human breast cancer lines and the MCF10AT model of human premalignant, proliferative breast disease. Methods in Mammary Gland Biology & Breast Cancer Research, Sept 2000.
23. Heppner, GH, Miller, FR, Shekhar, PVM. Non-transgenic models of Breast Cancer. Breast Cancer Research, 2000, 2:331-334.
24. Visscher, DW, Nanjia-Makker, P, Heppner, GH, Shekhar, PVM. Tamoxifen suppresses histologic progression to atypia and DCIS in MCF10AT xenografts, a model of early human breast cancer. Breast Cancer Research and Treatment 65: 41-47, 2001.
25. Santner, SJ, Dawson, PJ, Tait, L, Soule, HD, Eliason, J, Mohamed, AN, Wolman, SR, Heppner, GH, Miller, FR. Malignant MCF10CA1 cell lines derived from premalignant human breast epithelial MCF10AT cells. Breast Cancer Research & Treatment 65: 101-110, 2001.