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Education
Va Polytechnic Institute & State University, Blackburg, VA BS 1974 Biology
Medical College of Virginia, Richmond, VA Ph.D. 1979 Anatomy
Washington University School of Medicine, St. Louis, MO Post-Doc 1981 Neurochemistry
Positions and Employment
Professional Experience
1975-1979 Pre-doctoral Fellow, Dept. of Anatomy, (Dr. J.T. Povlishock) Med. College of Virginia, Richmond, VA
1979-1981 Post-doctoral Fellow, Dept. of Pharmacology, (Dr. O. H. Lowry) Washington Univ, St. Louis, MO
1981-1986 Assist. Professor of Neurology & Cell Biology & Anatomy, University of Miami School of Medicine
1986-1993 Assoc. Professor of Neurology & Cell Biology & Anatomy, University of Miami School of Medicine
1993-Present Professor of Neurology & Cell Biology & Anatomy, University of Miami School of Medicine
1995-1997 Vice Chairman for Basic Science Affairs, Neurology, University of Miami School of Medicine
1997-Present Scientific Director, The Miami Project to Cure Paralysis, University of Miami School of Medicine
1997-Present Professor of Neurological Surgery, University of Miami School of Medicine
1997-Present Kinetic Concepts Distinguished Chair in Neurosurgery, University of Miami School of Medicine
1997-Present Vice Chairman for Academic Affairs, Neurological Surgery, University of Miami School of Medicine
Other Experience/Memberships/Honors
1984-1989 Established Investigator of the American Heart Association
1988 Co-chairman, Sixteenth Research Princeton Conference
1994 Virginia Commonwealth University Health Science Alumni Award
1996 Excellence in Mentorship in Neuroscience, University of Miami School of Medicine
1996-Present Director, Neurotrauma Research Center
1996-1999 Brain Research Study Committee, American Heart Association
1996-1997 Vice President of National Neurotrauma Society
1997 Provost's Award for Scholarly Activity
1997-Present Kentucky Brain and Spinal Cord Injury Study Committee
1999-2000 President of National Neurotrauma Society
1999-Present Editorial Boards - J Cerebral Blood Flow & Metabolism, J Neuropath Exp Neurol, J Neurotrauma
2002 Chairman, First Joint National and International Neurotrauma Symposium
Selected Publications in Refereed Journals
Prado R, Dietrich WD, Watson BD, Ginsberg MD, Green BA. (1987) Photochemically induced graded spinal cord infarction: Behavioral, electrophysiological, and morphological correlates. J Neurosurg 67(5):745-753.
Humphrey MF, Levy WJ, Dietrich WD, Rumpf R, Mora J. (1989) Peripheral nerve repair across a gap studied by repeated observation in a new window implant chamber. Brain Res 497(1):132-137.
Dietrich WD, Alonso O, Busto R, Globus M Y-T, Ginsberg MD. (1994) Post-traumatic brain hypothermia reduces histopathological damage following concussive brain injury in the rat. Acta Neuropathol 87(3):250-258.
Dietrich WD, Alonso O, Halley M. (1994) Early microvascular and neuronal consequences of traumatic brain injury: A light and electron microscopic study in rats. J Neurotrauma 11(3):289-301.
Bramlett HM, Green EJ, Dietrich WD, Busto R, Globus MY-T, Ginsberg MD. (1995) Post-traumatic brain hypothermia provides protection from sensorimotor and cognitive behavioral deficits. J Neurotrauma 12(3):289-298.
Globus MY-T, Alonso O, Dietrich WD, Busto R, Ginsberg MD. (1995) Glutamate release and free radical production following brain injury: Effects of posttraumatic hypothermia. J Neurochem 65(4):1704-1711.
Dietrich WD, Alonso O, Busto R, Finklestein SP. (1996) Posttreatment with intravenous basic fibroblast growth factor reduces histopathological damage following fluid percussion brain injury in rats. J. Neurotrauma 13(6):309-316.
Dietrich WD, Alonso O, Busto R, Prado R, Dewanjee S, Dewanjee MK, Ginsberg MD. (1996) Widespread hemodynamic depression and focal platelet accumulation after fluid percussion brain injury: A double-label autoradiographic study in rats. J Cereb Blood Flow Metabol 16(3):481-489.
Dietrich WD, Alonso O, Halley M, Busto R. (1996) Delayed posttraumatic brain hyperthermia worsens outcome after fluid percussion brain injury: A light and electron microscopic study in rats. Neurosurgery 38(3):533-541.
Yezierski RP, Liu S, Ruenes GL, Busto R, Dietrich WD. (1996) Neuronal damage following intraspinal injection of a nitric oxide synthase inhibitor in the rat. J Cereb Blood Flow Metabol 16(5):996 1004.
Bramlett HM, Dietrich WD, Green EJ, Busto R. (1997) Chronic histopathological consequences of fluid percussion brain injury in rats: Effects of post-traumatic hypothermia. Acta Neuropath 93(2):190-199.
Bramlett HM, Kraydieh S, Green EJ, Dietrich WD. (1997) Temporal and regional patterns of axonal damage following traumatic brain injury: A beta-amyloid precursor protein immunocytochemical study in rats. J Neuropathol Exp Neurol 56(10):1132-1141.
Bethea JR, Castro M, Keane RW, Lee TT, Dietrich WD, Yezierski, RP. (1998) Traumatic spinal cord injury induces nuclear factor-?B activation. J Neurosci 18(9):3251-3260
Bethea JR, Nagashima H, Acosta MC, Briceno C, Gomez F, Marcillo AE, Loor K, Green J, Dietrich WD. (1999) Systemically administered Interleukin-10 reduces tumor necrosis factor-alpha production and significantly improves functional recovery following traumatic spinal cord injury in rats. J Neurotrauma 16(10):851-863.
Chatzipanteli K, Wada K, Busto R, Dietrich WD. (1999) Effects of moderate hypothermia on constitutive and inducible nitric oxide synthase activities after traumatic brain injury in the rat. J Neurochem 72(5):2047-2052.
Lee TT, Green BA , Dietrich WD, Yezierski RP. (1999) Neuroprotective effects of basic fibroblast growth factor following spinal cord contusion injury in the rat. J Neurotrauma 16(5):347-356.
Sanders MJ, Dietrich WD, Green EJ. (1999) Cognitive function following traumatic brain injury: Effects of injury severity and recovery period in a parasagittal fluid percussive injury model. J Neurotrauma 16(10):915-925.
Truettner J, Schmidt-Kastner R, Busto R, Alonso OF, Loor JY, Dietrich WD, Ginsberg MD. (1999) Expression of brain-derived neurotrophic factor, nerve growth factor, and heat shock protein HSP70 following fluid percussion brain injury in rats. J Neurotrauma 16(6):471-486.
Wada K, Alonso OF, Busto R, Panetta J, Clemens JA, Ginsberg MD, Dietrich WD. (1999) Early treatment with a novel inhibitor of lipid peroxidation (LY341122) improves histopathological outcome after moderate fluid percussion brain injury in rats. Neurosurg 45(3):601-608.
Bruce JH, Norenberg MD, Kraydieh S, Puckett W, Marcillo AE, Dietrich WD. (2000) Schwannosis: Role of gliosis and proteoglycan in human spinal cord injury. J Neurotrauma 17(9):781-788.
Chatzipanteli K, Yanagawa Y, Marcillo AE, Kraydieh S, Yezierski RP, Dietrich WD. (2000) Posttraumatic hypothermia reduces polymorphonuclear leukocyte accumulation following spinal cord injury in rats. J Neurotrauma 17(4):321-332.
Yu CG, Jimenez O, Marcillo AE, Weider B, Bangerter K, Dietrich WD, Castro S, Yezierski RP. (2000) Beneficial effects of modest systemic hypothermia on locomotor function and histopathological damage following contusion-induced spinal cord injury in rats. J Neurosurg 93(1 Suppl):85-93.
Bramlett HM, Dietrich WD. (2001) Neuropathological protection after traumatic brain injury in intact female rats versus males or ovariectomized females. J Neurotrauma, 18(9):891-900.
Keane RW, Kraydieh S, Lotocki G, Bethea JR, Krajewski S, Reed JC, Dietrich WD. (2001) Apoptotic and anti-apoptotic mechanisms following spinal cord injury. J Neuropathol Exp Neurol 60(5):422-429.
Matsushita Y, Bramlett HH, Alonso O, Dietrich WD. (2001) Posttraumatic hypothermia is neuroprotective in a model of traumatic brain injury complicated by a secondary hypoxic insult. Crit Care Med 29(11):2060-2066.
Passineau MJ, Green EJ, Dietrich WD. (2001) Therapeutic effects of environmental enrichment on cognitive function and tissue integrity following severe traumatic brain injury in rats. Exp Neurol 168(2):373-384.
Yanagawa Y, Marcillo AE, Garcia-Rojas R, Loor KE, Dietrich WD. (2001) Influence of posttraumatic hypoxia on behavioral recovery and histopathological outcome following moderate spinal cord injury in rats. J Neurotrauma 18(6):635-644.
Yu C-G, Jagid J, Ruenes G, Dietrich WD, Marcillo AE, Yezierski RP. (2001) Detrimental effects of systemic hyperthermia on locomotor function and histopathological outcome after traumatic spinal cord injury in the rat. Neurosurgery 49(1):152-159.
Barnes G, Benjamin S, Bowen JD, Cutter N, de Lateur BJ, Dietrich WD, et al. (2002) Proposed diagnostic criteria and nosology of acute transverse myelitis. The Transverse Myelitis Consortium Working Group Members. Neurology, 59:499-505.
Bethea JR, Dietrich WD (2002) Targeting the host inflammatory response in traumatic spinal cord injury. Curr Opin Neurol 15(3):355-360.
Chatzipanteli K, Garcia, R, Marcillo AE, Loor KE, Kraydieh S, Dietrich WD. (2002) Temporal and segmental distribution of constitutive and inducible nitric oxide synthases following traumatic spinal cord injury: Effect of aminoguanidine treatment. J Neurotrauma 19(5):639-651.
Kinoshita K, Chatzipanteli K, Alonso OF, Howard M, Dietrich WD. (2002) The effect of brain temperature on hemoglobin extravasation after traumatic brain injury. J Neurosurg, 97(4):945-953.
Kinoshita K, Chatzipanteli K, Vitarbo E, Truettner JS, Alonso OF, Dietrich WD. (2002) Interleukin-1ß messenger ribonucleic acid and protein levels after fluid percussion brain injury in rats: The importance of injury severity and brain temperature. Neurosurgery 51(1):195-203.
Kinoshita K, Kraydieh S, Alonso O, Hayashi N, Dietrich WD. (2002) Effect of post-traumatic hyperglycemia on contusion volume and neutrophil accumulation after moderate fluid-percussion brain injury in rats. J Neurotrauma 19(6):681-692.
Ozawa H, Keane RW, Marcillo AE, Diaz PH, Dietrich WD. (2002) Therapeutic strategies targeting caspase inhibition following spinal cord injury in rats. Experimental Neurology 177(1):306-313.
Baskin YK, Dietrich WD, Green EJ. (2003) Two effective behavioral tasks for evaluating sensorimotor dysfunction following traumatic brain injury in mice. J Neurosci Methods, 129(1):97-83.
Dietrich WD. (2003) Confirming an experimental therapy prior to transfer to humans: What is the ideal? J Rehab Res & Dev, 40:63-69, 2003.
Lotocki G, Alonso OF, Frydel B, Dietrich WD, Keane RW. (2003) Monoubiquitination and cellular redistribution of XIAP in neurons after traumatic brain injury. J Cereb Blood Flow Metab, 23(10):1129-1136.
Pearse DD, Chatzipanteli, Marcillo AE, Bunge MB, Dietrich WD. (2003) Comparison of iNOS inhibition by antisense and pharmacological treatments after spinal cord injury. J Neuropath Exp Neurol, 62(11):1096-1107
Vitarbo E, Chatzipanteli K, Kinoshita K, Truettner JS, Alonso, OF, Dietrich WD. (2004) Tumor necrosis factor alpha expression and protein levels following fluid percussion injury in rats: The effect of injury severity and brain temperature. Neurosurgery 55(2):416-424.
Urrea C, Danton GH, Dietrich WD. (2004) The beneficial effect of mild hypothermia in a rat model of repeated thromboembolic insults. Acta Neuropathol, 107(5):413-420.
Lotocki G, Alonso OF, Dietrich WD, Keane RW (2004) TNF receptor 1 and its signaling intermediates are recruited to lipid rafts in the traumatized brain. J Neurosci 24(49):11010-11016.
Hu B, Liu C, Bramlett H, Sick TJ, Chen S, Alonso OF, Dietrich WD (2004) Activation of TrkB – ERK ½ - CREB/Elk-1 Pathways in hippocampal mossy fiber organization after traumatic brain injury. J Cereb Blood Flow Metab 24 (8):933-943.
Danton GH, Dietrich WD (2004) The search for neuroprotective strategies in stroke. Am J Neuroradiol, 25(2):181-194.
Bramlett HM, Dietrich WD (2004) Pathophysiology of cerebral ischemia and brain trauma. Similarities and differences. J Cereb Blood Flow Metab, 24(2):133-150.
Suzuki T, Bramlett HM, Dietrich WD (2004) The effects of post-traumatic hyperthermia in female and ovariectomized rats. J Neurotrauma 21(7):842-853.
Truettner JS, Suzuki T, Dietrich WD (2005) The effect of therapeutic hypothermia on the expression of inflammatory response genes following moderate traumatic brain injury in the rat. Molec Brain Res 138:124-134.
Pearse DD, Lo TP, Cho KS, Lynch MA, Garb MS, Marcillo AE, Sanchez AR, Bunge MB, Dietrich WD (2005) Histopathological and behavioral characterization of a novel cervical spinal cord displacement contusion injury in the rat. J Neurotrauma 22:680-702.
Eshraghi AA, Nehme O, Polak M, He J, Alonso OF, Dietrich WD, Balkany TJ, Van De Water TR (2005) Cochlear temperature correlates with both temporalis muscle and rectal temperatures. Application for testing the otoprotective effect of hypothermia. Acta Otolaryngol 125(9):922-928.
Bramlett HM, Dietrich WD, Alonso O, Green EJ (2005) Effect of bone morphogenetic protein-7 (BMP-7) treatment on behavior after traumatic brain injury in rats. Int J Neuroprotection Neuroregeneration 1(3):165-170.
Blits B, Kitay BM, Farahvar A, Caperton CV, Dietrich WD, Bunge MB (2005) Lentiviral vector-mediated transduction of neural progenitor cells before implantation into injured spinal cord and brain to detect their migration, deliver neurotrophic factors and repair tissue. Restor Neurol Neurosci 23:313-324.
Truettner JS, Alonso OF, Dietrich WD (2005) Influence of therapeutic hypothermia on matrix metalloproteinase activity after traumatic brain injury in rats. J Cereb Blood Flow Metab 25:1505-1516.
Keane RW, Davis A, Dietrich WD (2006) Inflammatory and apoptotic signaling following spinal cord injury. J Neurotrauma 23(3/4):335-344.
Lotocki G, Keane RW, Alonso OF, Curbello K, Dietrich WD (2006) Therapeutic hypothermia modulates TNFR1 signaling in the traumatized brain via early transient activation of the JNK pathway and suppression of XIAP cleavage. Eur J Neurosci 24:2283-2290.
Fleming JC, Norenberg MD, Ramsay DA, Dekaban GA, Marcillo AE, Saenz AD, Pasquale-Styles M, Dietrich WD, Weaver LC. (2006) The cellular inflammatory response in human spinal cords after injury. Dec;129(Pt 12):3249-69.
Lyden PD, Krieger D, Yenari M, Dietrich WD (2006) Therapeutic hypothermia for acute stroke. International Stroke Society, International Journal of Stroke Feb 1:9-19.
Atkins CM, Chen S, Alonso OF, Dietrich WD, Hu B (2006) Activation of calcium/calmodulin-dependent protein kinases after traumatic brain injury. J Cereb Blood Flow Metab 26:1507-1518.
Lane MA, Truettner JS, Brunschwig J-P, Gomez A, Bunge MB, Dietrich WD, Dziegielewska KM, Elk CJ, VandeBerg JL, Saunders NR (2007) Age-related differences in the local cellular and molecular responses to injury in developing spinal cord of the opossum, Monodelphia domestica. Eur J Neurosci 25:1725-1742.
Lozano JD, Abulafia P, Danton GH, Watson BD, Dietrich WD (2007) Characterization of a thromboembolic photochemical model of repeated stroke in mice. J Neuroscience Methods 162:244-254.
Truettner JS, Hu B, Alonso OF, Bramlett HM, Kokame K, Dietrich WD (2007) Subcellular stress response after traumatic brain injury. J Neurotrauma 4:599-612.
Chen S, Atkins CM, Liu CL, Alonso OF, Dietrich WD, Hu B (2007) Alterations in mammalian target of rapamycin signaling pathways after traumatic brain injury. J Cereb Blood Flow Metab 27(5):939-49.
Dietrich WD, Bramlett HM (2007) Hyperthermia and central nervous system injury. Prog Brain Res 162:201-217.
Urrea C, Castellanos DA, Sagen J, Tsoulfas P, Bramlett HM, Dietrich WD (2007) Widespread cellular proliferation and focal neurogenesis after traumatic brain injury in the rat. Restor Neurol Neurosci 25(1):65-76.
Davis AR, Lotocki G, Marcillo AE, Dietrich WD, Keane RW (2007) FasL, Fas, and Death-Inducing Signaling Complex (DISC) Proteins Are Recruited to Membrane Rafts after Spinal Cord Injury. J Neurotrauma 24(5): 823-834.
Kuluz JW, Prado R, He S, Zhao W, Dietrich WD, Watson B. (2007) New Pediatric Model of Ischemic Stroke in Infant Piglets by Photothrombosis. Stroke 38(6):1932-7.
Atkins, CM, Oliva, Jr, AA, Alonso OF, Chen S, Bramlett HM, Hu BR, Dietrich WD (2007) Hypothermia treatment potentiates ERK1/2 activation after traumatic brain injury. Eur J Neurosci 26:810-819.
Atkins CM, Oliva, Jr. AA, Alonso OF, Pearse DD, Bramlett HM, Dietrich WD (2007) Modulation of the cAMP signaling pathway after traumatic brain injury. Exp Neurol. 208(1):145-158.
Utagawa A, Truettner JS, Dietrich WD, Bramlett HM (2008) Systemic inflammation exacerbates behavioral and histopathological consequences of isolated traumatic brain injury in rats. Exp Neurol. 211/1:283-291.
de Rivero Vaccari JP, Lotocki G, Marcillo AE, Dietrich WD, Keane RW (2008) A molecular platform in neurons regulates inflammation after spinal cord injury. J Neurosci 28(13):3404-14.
Liu CL, Chen S, Dietrich D, Hu BR (2008) Changes in autophagy after traumatic brain injury. J Cereb Blood Flow Metab. 28(4):674-83.
Utagawa A, Bramlett HM, Daniels L, Lotocki G, Dekaban GA, Weaver LC, Dietrich WD (2008) Transient blockage of the CD11d/CD18 integrin reduces contusion volume and macrophage infiltration after traumatic brain injury in rats. Brain Res. 1207C:155-163.
Pinzon A, Marcillo A, Pabon-Romero D, Bunge MB, Dietrich WD (2008) Evaluation of erythropoietin as a neuroprotective agent in rat spinal cord contusion and compression models. Exp Neurol. (In Press)
Research Support
NINDS NO1-NS-3-2352 (Dietrich, P.I.) 01/31/03-01/30/08 Year 1 - $125,789 Total Award $697,326
Facilities of Research for SCI - Replication of Studies
This contract will fund scientists to replicate exciting published studies in the area of SCI.
NINDS NO1-NS-3-2351 (Dietrich, P.I.) 01/31/03-01/30/08 Year 1 $165,036 Total Award $1,027,391
Facilities of Research for SCI - Outreach
This contract will fund two summer students, two postdoctoral fellows and one visiting scholar each year to investigate current problems in the area of SCI research.
1 RO1 NS42133-02 (Dietrich, P.I.) 04/15/02-03/31/07 Year $235,000 Total Award $1,081,000
NIH/NINDS - The Importance of Temperature on Inflammation after Traumatic Brain Injury
To build on previous studies showing that post-traumatic temperature manipulations significantly influence inflammatory processes and investigate the cellular, biochemical, and molecular mechanisms underlying these inflammatory events after TBI.
T32 NS07459-06 (Dietrich, P.I.) 7/1/05 – 6/30/10 Year Total Award: $696.310 – Training Program in CNS Injury and Repair To guide trainees through the process of acquiring the research skills and intellectual vigor required to becoming independent clinically informed neuroscientists.
USAMRMC U.S. Army Medical Research and Materiel Command (Dietrich, P.I.) 11/1/06 – 10/31/10 Total Award: $958.256 - The use of lentiviral-vector-mediated transduction of neural progenitor cells to repair the brain after traumatic brain injury
USAMRMC U.S. Army Medical Research and Materiel Command (Dietrich, P.I.) 11/8/04 – 11/7/08 Total Award: $1,612,000 - Battlefield Exercise and Combat Related Spinal Cord Injury
NINDS 1 RO1 NS 56072-01 (Dietrich, P.I.) 3/1/07 – 2/28/12 Total Award: $1,668,441 - Cyclic Nucleotide Regulation in Traumatic Brain Injury.
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